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Related Experiment Videos

A prospective, randomized study: day 3 versus hatching blastocyst stage.

Takafumi Utsunomiya1, Hiroko Ito, Miyuki Nagaki

  • 1St Luke Clinic, 5, Tsumori-Tomioka, Oita City 870-0947, Japan. st-luke@oct-net.ne.jp

Human Reproduction (Oxford, England)
|May 15, 2004
PubMed
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Hatching blastocyst embryo transfer (ET) showed no significant advantage over day 3 ET for pregnancy and implantation rates in this randomized study. Further analysis of hatching blastocyst ET day 5-6 versus day 7-9 showed improved outcomes.

Area of Science:

  • Reproductive Medicine
  • Embryology
  • In Vitro Fertilization (IVF)

Background:

  • Recent advances in human IVF-embryo transfer (ET) include sequential media and blastocyst stage ET.
  • Previous prospective, randomized studies indicated no advantage of blastocyst stage ET over day 3 ET.

Purpose of the Study:

  • To evaluate and compare implantation and pregnancy rates of hatching blastocyst stage ET versus conventional day 3 ET.

Main Methods:

  • A prospective, randomized study involving 480 patient cycles.
  • Comparison of pregnancy and implantation rates between day 3 ET (n=240) and hatching blastocyst stage ET (Hat ET; n=240).

Main Results:

  • The hatching blastocyst ET group had a pregnancy rate of 29.3% and an implantation rate of 21.4%.

Related Experiment Videos

  • The day 3 ET group had a pregnancy rate of 29.2% and an implantation rate of 19.1%.
  • Within the hatching blastocyst group, day 5-6 ET showed higher pregnancy, implantation, and ongoing pregnancy rates than day 7-9 ET.

    • Conclusions:

    • Embryo transfer with hatching stage blastocysts offers no significant advantage in pregnancy or implantation rates compared to conventional day 3 ET.