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[Long-term therapy of immune neutropenia with high-dose 7S immunoglobulin in a child]
K Schmitt1, G Tulzer, K Peherstorfer
1Internen Abteilung, Landes-Kinder-klinik Linz.
Insights
High-dose immunoglobulin therapy effectively managed recurrent infections in a child with immune neutropenia. This treatment maintained adequate neutrophil counts, preventing severe infections over nine months.
Area of Science:
- Pediatric Immunology
- Hematology
Background:
- Immune neutropenia presents a significant risk of recurrent infections.
- Neutrophil counts below 0.5 G/l indicate severe neutropenia.
Observation:
- A 15-month-old girl with suspected immune neutropenia experienced recurrent infections.
- Prior to treatment, her neutrophil counts were consistently below 0.5 G/l.
Findings:
- Monthly high-dose intravenous immunoglobulin therapy was administered for nine months.
- Neutrophil counts remained above 0.5 G/l, with only one exception during treatment.
- The patient showed a positive response to therapy and remained infection-free.
Implications:
- High-dose immunoglobulin therapy is a viable treatment option for immune neutropenia.
- Early consideration of this therapy may prevent life-threatening infections in affected children.
Abstract:
A 15 month old girl with suspected immune neutropenia was treated with high dose immunoglobulin because of recurrent infections over a period of 9 months. Before therapy her neutrophil counts were below 0.5 G/l. With monthly intravenous immunoglobulin her neutrophils remained above 0.5 G/l with one exception. Even after 9 months the patient responded well to therapy, she did not experience new episodes of infections. We suggest that in case of recurrent infections high dose immunoglobulin therapy should be considered in patients with immune neutropenia before the occurrence of life threatening infections.