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Ischemic stroke in young women: a nested case-control study using the UK General Practice Research Database.

Alison L Nightingale1, Richard D T Farmer

  • 1Postgraduate Medical School, University of Surrey, Stirling House, Surrey Research Park, Guildford, Surrey GU2 7DJ, United Kingdom.

Stroke
|May 15, 2004
PubMed
Summary

The incidence of ischemic stroke in UK women aged 15-49 is 3.56 per 100,000 annually. Key risk factors include heart disease, heavy alcohol use, and hypertension, while light alcohol consumption appears protective.

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Area of Science:

  • Neurology
  • Epidemiology
  • Public Health

Background:

  • Incidence of ischemic stroke in young women varies widely.
  • Previous estimates range from 0.9 to 8.9 per 100,000 per year.
  • Accurate incidence and risk factor data are crucial for this demographic.

Purpose of the Study:

  • To determine the incidence of ischemic stroke in young women in the UK.
  • To identify specific risk factors associated with ischemic stroke in this population.

Main Methods:

  • Utilized the UK General Practice Research Database for women aged 15-49 diagnosed between 1992-1998.
  • Calculated age-specific incidence rates.
  • Conducted a nested case-control study with matched controls and conditional logistic regression to determine odds ratios (ORs).

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Main Results:

  • The overall incidence of ischemic stroke was 3.56 per 100,000 person-years.
  • Significant risk factors identified: heart disease (OR, 10.5), heavy alcohol consumption (OR, 8.5), previous venous thromboembolism (OR, 6.2), treated diabetes mellitus (OR, 4.7), hypertension (OR, 4.6), migraine (OR, 2.3), and combined oral contraceptive use (OR, 2.3).
  • Light alcohol consumption showed a protective effect (OR, 0.17).

Conclusions:

  • The determined incidence rate is lower than reported in the USA and Europe but higher than in the UK Oxford Region.
  • Discrepancies may be due to under-reporting of mild cases or genuine regional differences.
  • Findings align with previous research on ischemic stroke in young women, highlighting key modifiable and non-modifiable risk factors.