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Updated: Jul 31, 2026

Evaluation of the Efficacy And Toxicity of RNAs Targeting HIV-1 Production for Use in Gene or Drug Therapy
Published on: September 5, 2016
[Interferonogenic activity of immobilized ribopolynucleotides in vitro]
N M Zholobak1, A P Mandzhos, S V Verevka
1Zabolotny Institute of Microbiology and Virology, National Academy of Sciences of Ukraine, Kyiv.
Abstract:
In vitro experiments the authors have studied a property of yeast RNA--tilorone hydrochloride complex covalently linked to spheron to induce the synthesis of interferons type I (alpha- and beta-interferons) in the culture of peripheral mononuclear human cells. Such a complex is shown to possess a marked interferonogenic activity. The data obtained appear to be a proof of the interferon induction to be realised by a mechanism needing at the first stage the contact between the inducer and the cell surface without its penetration into the cell.
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