[Application of superoxide dismutase preparation for the prophylaxis of post-traumatic broncho-pulmonary...

The effectiveness of endobronchial application of superoxide dismutase (SOD) for prevention of posttraumatic bronchopulmonary complications was analyzed in 11 patients with severe combined traumas and dominating injuries of the chest. It was shown that severe combined traumas sharply initiate processes of free radical oxidation in tissues, intensify prooxidative activity, deplete total antioxidative activity and its important link--plasma and erythrocyte SOD. Endobronchial instillation of SOD after a severe combined trauma results in increased intracellular activity of catalase, total antioxidative activity, SOD, decreased production of lipid peroxides in homogenate of the pellet of bronchoalveolar lavage (BAL), reduced number of neutrophiles and higher number of lymphocytes in BAL pellet. Posttraumatic endobronchial instillation of SOD reliably improves the respiratory and metabolic function of the lungs, improves the surfactant system of the lungs, bronchial patency, reduces the number of cases of posttraumatic pneumonia.