Related Experiment Video
Updated: Aug 24, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
Published on: March 14, 2017
[Retrospective transfusional audit at the Centro Nacional de la Transfusión Sanguínea]
Eduardo Juárez-Rangel1, Maria Jezabel Vite-Casanova, Rafael A Marín y López
1Centro Nacional de la Transfusión Sanguínea, México, DF. rangel@avantel.net
Background:
Prior to a blood transfusion, we should consider the risk benefit ratio. The literature shows that 18 to 57% of red blood cells, up to 96% of fresh frozen plasma and 26% of platelet concentrates are unnecessarily transfused. The goal of the present work is to know the appropriateness of transfusion at public and private health institutions supported by the Centro Nacional de la Transfusión Sanguínea.
Material And Methods:
An observational, retrospective, transverse and descriptive study was carried out by analyzing the requirements of blood products considering the patient's diagnosis, requested blood components, complete blood count, prothrombin and activated partial thromboplastin time. The therapeutic indication was considered either adequate or inadequate according to the guidelines for the transfusion therapy of blood products. Descriptive statistics for the analysis of the data were used.
Results:
We analyzed 1,573 request forms received in year 2001. In 849 cases (55%) the indication was adequate, whereas in 724 (45%) the indication of the blood products was inadequate.
Conclusions:
Our results show that overtransfusion is a common practice. We propose to follow the guidelines already established for the transfusion of blood components in order to avoid iatrogenia due to overtransfusion.
Related Concept Videos
Blood Transfusion
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Blood Transfusion and Agglutination
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Continuous Renal Replacement Therapy