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[Metabolic syndrome strongly linked to stroke in Chinese]

Xiang-feng Dou1, Hong-ye Zhang, Kai Sun

  • 1Sino-German Lab for Molecular Medicine, Fuwai Hospital, Chinese Academy of Medical Science, Beijing 100037, China. douxiangfeng@yahoo.com.cn

Zhonghua Yi Xue Za Zhi
|May 18, 2004
PubMed

Insights

Metabolic syndrome, defined by ATP III or Chinese criteria, significantly increases stroke risk in Chinese adults. This highlights the need for further prospective studies to confirm the link between metabolic syndrome and stroke.

Area of Science:

  • Cardiovascular Epidemiology
  • Metabolic Disorders
  • Neurology

Background:

  • Metabolic syndrome is a cluster of conditions that increase the risk of heart disease, stroke, and diabetes.
  • The prevalence and impact of metabolic syndrome on stroke risk in the Chinese population require further investigation.

Purpose of the Study:

  • To evaluate the association between metabolic syndrome and stroke in Chinese individuals.
  • To compare the diagnostic criteria of ATP III and a revised Chinese definition for abdominal obesity in relation to stroke risk.

Main Methods:

  • A multi-center case-control study involving 1934 first-ever stroke patients (aged 30-74) and 1839 matched controls.
  • Stroke subtypes included atherothrombosis, lacunar infarction, and intracerebral hemorrhage.
  • Data analysis involved age- and sex-adjusted models, with further adjustments for cholesterol, smoking, drinking, and education.

Main Results:

  • The prevalence of metabolic syndrome was significantly higher in stroke patients compared to controls.
  • Metabolic syndrome, by ATP III criteria, was associated with a 2.7-4.3 fold increased risk for lacunar infarction and cerebral atherosclerosis.
  • Metabolic syndrome, by ATP III criteria, was associated with a 2.5-4.0 fold increased risk for intracerebral hemorrhage.

Conclusions:

  • Metabolic syndrome, using both ATP III and revised Chinese criteria, is positively associated with increased stroke risk in the Chinese population.
  • The findings emphasize the importance of managing metabolic syndrome to mitigate stroke risk.
  • Further well-designed prospective studies are recommended to strengthen the evidence linking metabolic syndrome and stroke in Chinese individuals.
Abstract

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