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Updated: Aug 24, 2026
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Proton therapy for prostate cancer: the initial Loma Linda University experience
Jerry D Slater1, Carl J Rossi, Les T Yonemoto
1Department of Radiation Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA.
Purpose:
We analyzed results of conformal proton radiation therapy for localized prostate cancer, with emphasis on biochemical freedom from relapse.
Methods And Materials:
Analyses were performed for 1255 patients treated between October 1991 and December 1997. Outcomes were measured on primarily in terms of biochemical relapse and toxicity.
Results:
The overall biochemical disease-free survival rate was 73%, and was 90% in patients with initial PSA
Conclusions:
Conformal proton radiation therapy at the reported dose levels yielded disease-free survival rates comparable with other forms of local therapy, and with minimal morbidity. Dose-escalation strategies are being implemented to further improve long-term results.
