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Related Experiment Videos

Hepatitis E in pregnancy.

A Kumar1, M Beniwal, P Kar

  • 1Department of Obstetrics and Gynaecology, Maulana Azad Medical College, New Delhi, India. ashkumar@eth.net

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|May 18, 2004
PubMed
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Hepatitis E infection in pregnant women during the third trimester can lead to severe outcomes, including fulminant hepatic failure, preterm labor, and high mortality rates. Vertical transmission of Hepatitis E virus (HEV) was also observed.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Maternal-Fetal Medicine

Background:

  • Viral hepatitis during pregnancy poses significant risks to both mother and fetus.
  • Hepatitis E virus (HEV) is an emerging concern in pregnant populations, particularly in endemic areas.
  • Understanding the clinical spectrum and outcomes of HEV infection in pregnancy is crucial for timely management.

Purpose of the Study:

  • To investigate the clinical and biochemical presentation of viral hepatitis E in pregnant women.
  • To determine the spectrum of viral hepatitis, with a focus on HEV, in pregnant women presenting with jaundice.
  • To assess the maternal and fetal outcomes associated with HEV infection during pregnancy.

Main Methods:

  • Prospective analysis of sera from 62 pregnant women with jaundice in the third trimester.

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  • Testing for markers of hepatitis A, B, C, and E viruses.
  • Serological and molecular testing (IgM anti-HEV, HEV-RNA) on cord blood from HEV-positive mothers.

    • Main Results:

    • Hepatitis E virus (HEV) accounted for 45.2% of jaundice cases in pregnant women.
    • HEV was responsible for 81% of fulminant hepatic failure (FHF) and 37.25% of acute viral hepatitis cases.
    • HEV infection was associated with a 26.9% mortality rate, 33.3% vertical transmission, and approximately two-thirds of cases experiencing preterm deliveries.

    Conclusions:

    • Hepatitis E infection in the third trimester of pregnancy frequently leads to severe disease, including FHF in one-third of cases.
    • HEV infection during pregnancy is linked to high incidences of preterm labor and maternal mortality.
    • The findings underscore the critical need for vigilance and management strategies for HEV in pregnant women.