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Updated: Aug 5, 2026
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
Polymorphism p53 codon-72 and invasive cervical cancer: a meta-analysis
1Department of Epidemiology and Health Promotion, Graduate School of Health Science and Management, Yonsei University, Seoul, South Korea. jsunha@yumc.yonsei.ac.kr
Summary
The p53 gene
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- The p53 gene codon 72 arginine isoform's role in invasive cervical cancer susceptibility is debated.
- Previous studies present conflicting evidence regarding this association.
Purpose of the Study:
- To quantitatively synthesize existing evidence on the p53 gene codon 72 arginine isoform and invasive cervical cancer risk.
- To clarify the controversial relationship between p53 polymorphism and cancer susceptibility.
Main Methods:
- A comprehensive literature search of MEDLINE and bibliographies was conducted.
- Thirty-seven studies were included, with data abstracted by two reviewers.
- The Mantel-Haenzel method was used to estimate the overall odds ratio (OR).
Main Results:
- An overall increased risk of cervical cancer was observed for the homozygous mutant (Arg/Arg) p53 genotype (OR=1.2).
- The Arg/Arg genotype was significantly associated with increased risk in adenocarcinomas but not squamous cell carcinomas.
- A significant association was found between the Arg/Arg genotype and HPV type 16 infection.
Conclusions:
- The p53 gene is associated with an increased risk of invasive cervical cancer.
- This risk is modulated by geographical location, cellular type, and human papillomavirus (HPV) type.
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