Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dynamics of nuclear pore complex organization through the cell cycle.

Gwénaël Rabut1, Péter Lénárt, Jan Ellenberg

  • 1Gene Expression and Cell Biology/Biophysics Programmes, European Molecular Biology Laboratory, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.

Current Opinion in Cell Biology
|May 18, 2004
PubMed
Summary

Nuclear pore complexes (NPCs) facilitate macromolecule transport in eukaryotic cells. Emerging evidence points to a stable NPC scaffold with dynamic components, suggesting mechanisms for regulating nuclear transport and cellular state.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Deterministic Acceptance Limits for Statistical Equivalence Testing in Hydrogen/Deuterium Exchange Mass Spectrometry.

Journal of the American Society for Mass Spectrometry·2026
Same author

Mitotic entry: Bora takes Polo to Aurora, and gives them a hug.

The EMBO journal·2026
Same author

Timing of mortality during development alters the evolution of aging.

BMC ecology and evolution·2025
Same author

Phosphoproteomic identification of Mos-MAPK targets in meiotic cell cycle and asymmetric oocyte divisions.

The Journal of cell biology·2025
Same author

Hydrophobic interactions of FG-nucleoporins are required for dilating nuclear membrane pores into selective transport channels after mitosis.

bioRxiv : the preprint server for biology·2025
Same author

Direct mechanical communication of cellular to nuclear shapes in oocytes.

Biophysical journal·2025

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biophysics

Background:

  • Nuclear pore complexes (NPCs) are essential gateways regulating transport between the nucleus and cytoplasm in eukaryotic cells.
  • While the protein components (nucleoporins) of NPCs are known, their assembly and structural organization remain poorly understood.
  • Understanding NPC structure is crucial for deciphering cellular transport regulation.

Purpose of the Study:

  • To investigate the structural organization of nuclear pore complexes (NPCs).
  • To explore the dynamic nature of NPC components and their potential roles in regulating transport.
  • To identify potential targets for modulating NPC function and cellular state.

Main Methods:

  • The study integrates recent experimental data and theoretical models.

Related Experiment Videos

  • Focuses on analyzing the proposed scaffold-and-module model of NPC architecture.
  • Examines implications of dynamic component assembly on NPC function.

    • Main Results:

    • Recent data suggest NPCs possess a stable scaffold with dynamically assembled, exchangeable components.
    • This modular organization implies NPCs are not static structures.
    • The dynamic parts of NPCs could be key sites for functional regulation.

    Conclusions:

    • NPCs are likely composed of a stable core structure with adaptable, exchangeable modules.
    • These dynamic components offer potential targets for altering nuclear transport properties.
    • Modulating NPC dynamics may represent a novel mechanism to influence cellular states.