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Related Experiment Videos

Acute-phase reactants and acute bacterial otitis media.

M A Del Beccaro1, P M Mendelman, A F Inglis

  • 1Emergency Services, Children's Hospital and Medical Center, Seattle, WA 98105.

American Journal of Diseases of Children (1960)
|September 1, 1992
PubMed
Summary
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Elevated erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels are common in acute bacterial otitis media. These elevated levels may also indicate a higher risk of recurrent otitis media in children.

Area of Science:

  • Pediatric infectious diseases
  • Clinical immunology
  • Biomarkers in infection

Background:

  • Acute bacterial otitis media is a common childhood infection.
  • Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are inflammatory markers.
  • The role of ESR and CRP in uncomplicated otitis media requires clarification.

Purpose of the Study:

  • To investigate if ESR and CRP levels are elevated in children with acute bacterial otitis media.
  • To determine the association between elevated ESR or CRP and recurrent otitis media.

Main Methods:

  • Investigator-blinded antibiotic efficacy trial in an urban children's hospital emergency department.
  • Thirty-one children with acute bacterial otitis media symptoms (duration ≤7 days) were enrolled.

Related Experiment Videos

  • Tympanocentesis, 10-day oral antibiotic treatment, and 30-day follow-up were performed.

    • Main Results:

    • 55% of patients had elevated ESR (>20 mm/h) or CRP (>8 mg/L).
    • 35% of patients experienced recurrent otitis media during follow-up.
    • Elevated ESR or CRP was associated with an 8.24-fold increased risk of recurrence (P = .007).

    Conclusions:

    • Elevated ESR and CRP levels are consistent with acute bacterial otitis media.
    • These inflammatory markers may indicate an increased risk of otitis media recurrence.
    • ESR and CRP could potentially aid in assessing recurrence risk in future studies.