Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radiotherapy-induced thyroid disorders.

Barbara A Jereczek-Fossa1, Daniela Alterio, Jacek Jassem

  • 1Department of Radiation Oncology, European Institute of Oncology, 435 via Ripamonti, 20141 Milan, Italy. barbara.fossa@ieo.it

Cancer Treatment Reviews
|May 18, 2004
PubMed
Summary

Radiotherapy to the neck can cause thyroid problems, including hypothyroidism and cancer, affecting up to 30% of patients. Early detection and advanced radiation techniques can improve management of these radiation-induced thyroid injuries.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SBRT plus abiraterone acetate and ADT versus abiraterone acetate and ADT in oligometastatic castrate-resistant prostate cancer (ARTO): long-term, unplanned overall survival analysis of an open-label, randomised, phase 2 trial.

The Lancet. Oncology·2026
Same author

Prevalence of Dental Caries in Adults Scheduled for Hematopoietic Stem Cell Transplantation: A Multicenter Study in a Polish Population.

Cancers·2026
Same author

Stereotactic arrhythmia radioablation for refractory ventricular tachycardia: the STOPSTORM.eu study.

European heart journal·2026
Same author

Tackling external validation challenges: experience with normal tissue complication probability (NTCP) models for head and neck cancer radiotherapy toxicities.

La Radiologia medica·2026
Same author

Efficacy and tolerability of hypofractionated and dose-boosted radiotherapy for localised prostate cancer: a systematic review and meta-analysis.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology·2026
Same author

Proton therapy in breast cancer: bridging medical and radiation oncology.

Cancer treatment reviews·2026

Area of Science:

  • Endocrinology
  • Oncology
  • Radiation Oncology

Background:

  • Radiotherapy to the neck region can lead to various under-reported thyroid abnormalities.
  • Primary hypothyroidism is the most common dysfunction, affecting 20-30% of patients, with half developing it within 5 years.
  • The risk of radiation-induced thyroid cancer is significantly elevated (15-53 fold) compared to the non-irradiated population.

Purpose of the Study:

  • To highlight the under-estimation and under-reporting of radiotherapy-induced thyroid abnormalities.
  • To discuss the spectrum of thyroid sequelae following neck radiotherapy.
  • To review the risk factors, diagnostic approaches, and management strategies for radiation-induced thyroid injury.

Main Methods:

  • Review of existing literature on radiotherapy-induced thyroid dysfunction and neoplasms.

Related Experiment Videos

  • Analysis of risk factors including radiation dose, volume, and prior treatments.
  • Discussion of diagnostic protocols and follow-up procedures for thyroid radiation injury.

    • Main Results:

    • Primary hypothyroidism is the most frequent complication, occurring in 20-30% of patients.
    • Radiation-induced thyroid cancer risk is substantially increased.
    • Key risk factors for hypothyroidism include total radiotherapy dose, irradiated thyroid volume, and prior thyroid surgery.

    Conclusions:

    • Minimizing radiation dose to the thyroid and pituitary gland is crucial.
    • Advanced radiotherapy techniques can improve dose distribution and reduce toxicity.
    • Regular thyroid function monitoring and timely intervention are essential for managing radiation-induced thyroid disorders.