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Updated: Aug 24, 2026

Preclinical Model of Prenatal Delta-9-Tetrahydrocannabinol Exposure to Assess Its Impact on Neurodevelopmental Outcomes
Published on: February 28, 2025
A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity
Susana Mato1, Vivien Chevaleyre, David Robbe
1Equipe INSERM Avenir, Plasticité synaptique: Maturation & Addiction, Institut Magendie des Neurosciences, Rue Camille Saint Saëns, 33077 Bordeaux, France.
Abstract:
Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.
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