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Catalytic ionic hydrogenations.

R Morris Bullock1

  • 1Chemistry Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA. bullock@bnl.gov

Chemistry (Weinheim an Der Bergstrasse, Germany)
|May 18, 2004
PubMed
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New catalytic ionic hydrogenation methods for ketones utilize proton and hydride transfer mechanisms. This approach, using inexpensive molybdenum and tungsten, differs from traditional metal-binding hydrogenation catalysts.

Area of Science:

  • Catalysis
  • Organic Chemistry
  • Organometallic Chemistry

Background:

  • Traditional ketone hydrogenation often requires ketone binding to the metal center.
  • Subsequent insertion into a metal-hydride (M-H) bond is a common mechanism in conventional catalysts.

Purpose of the Study:

  • To develop novel catalytic ionic hydrogenation methods for ketones.
  • To elucidate the distinct mechanistic steps involved in this catalytic process.

Main Methods:

  • Investigated catalytic ionic hydrogenation involving proton transfer from cationic metal dihydrides.
  • Studied hydride transfer from neutral metal hydrides.

Main Results:

  • Demonstrated a catalytic cycle distinct from traditional ketone hydrogenation pathways.

Related Experiment Videos

  • Developed effective ionic hydrogenation catalysts using earth-abundant molybdenum and tungsten.

    • Conclusions:

    • Catalytic ionic hydrogenation proceeds via a proton-then-hydride transfer mechanism.
    • Molybdenum and tungsten-based catalysts offer an efficient alternative for ketone hydrogenation.