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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Multi-step application of immobilized reagents and scavengers: a total synthesis of epothilone C
R Ian Storer1, Toshiyasu Takemoto, Philip S Jackson
1Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Abstract:
The total synthesis of the cytotoxic antitumour natural product epothilone C has provided a stage for the exploitation and further development of immobilized reagent methods. A stereoselective convergent synthetic strategy was applied, incorporating polymer-supported reagents, catalysts, scavengers and catch-and-release techniques to avoid frequent aqueous work-up and chromatographic purification.
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