Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of CD154 intensity on peripheral CD4+ T cells in autoimmune thyroid disease.

M Watanabe1, N Yamamoto, F Matsuzuka

  • 1Division of Biomedical Informatics, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Clinical and Experimental Immunology
|May 19, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel biallelic SZT2 mutations in 3 cases of early-onset epileptic encephalopathy.

Clinical genetics·2017
Same author

Low-risk papillary microcarcinoma of the thyroid: A review of active surveillance trials.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2017
Same author

Cytological features of solid variants of papillary thyroid carcinoma: a fine needle aspiration cytology study of 18 cases.

Cytopathology : official journal of the British Society for Clinical Cytology·2016
Same author

Expression of the Cyclodextrin Glucanotransferase Gene of Bacillus macerans in Bacillus brevis.

Bioscience, biotechnology, and biochemistry·2016
Same author

Thyroid follicular adenoma with numerous intracytoplasmic lumina mimicking yellow bodies: a case report.

Cytopathology : official journal of the British Society for Clinical Cytology·2016
Same author

Diffuse sclerosing variant of papillary thyroid carcinoma: a study of fine needle aspiration cytology in 20 patients.

Cytopathology : official journal of the British Society for Clinical Cytology·2013

Researchers studied CD154 molecule expression in Graves' disease (GD) and Hashimoto's disease (HD). Decreased CD154 on CD4+ T cells suggests a role in autoimmune thyroid disease pathogenesis, not severity.

Area of Science:

  • Immunology
  • Endocrinology
  • Autoimmune Diseases

Background:

  • Graves' disease (GD) and Hashimoto's disease (HD) are common autoimmune thyroid diseases.
  • Understanding immunological differences is crucial for diagnosis and treatment.
  • CD154 (CD40L) is a molecule involved in T cell-B cell interactions and T cell survival.

Purpose of the Study:

  • To investigate the expression of CD154 on peripheral T cells in patients with GD and HD.
  • To determine if CD154 expression levels correlate with disease severity in these conditions.

Main Methods:

  • Flow cytometry was used to analyze CD154 expression on CD4+ and CD8+ T cells.
  • Peripheral blood samples were collected from euthyroid patients with varying degrees of GD and HD.

Related Experiment Videos

Main Results:

  • CD154 expression was decreased on CD4+ T cells in both GD and HD patients compared to controls (not explicitly stated but implied).
  • No significant differences in CD154 expression on CD4+ T cells were observed between different disease severity groups.
  • CD8+ T cells did not express CD154 molecules.

Conclusions:

  • CD154 expression on CD4+ T cells is potentially involved in the pathogenesis of autoimmune thyroid diseases like GD and HD.
  • CD154 expression levels do not appear to be indicative of disease severity in these conditions.