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Related Experiment Videos

Sirolimus-induced angioedema.

Hani Wadei1, Scott A Gruber, Jose M El-Amm

  • 1Division of Nephrology, Department of Medicine, Wayne State University School of Medicine, Detroit, MI, USA.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
|May 19, 2004
PubMed
Summary

Sirolimus (SRL), an immunosuppressant, may cause angioedema (AE) in kidney transplant patients. This previously unrecognized side effect, particularly in African-American recipients, requires careful monitoring.

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Area of Science:

  • Nephrology
  • Immunology
  • Pharmacology

Background:

  • Sirolimus (SRL) is a widely used macrolide immunosuppressant in organ transplantation.
  • The complete spectrum of SRL side effects is not fully defined.
  • Angioedema (AE) is a potential adverse drug reaction.

Observation:

  • Three cases of SRL-induced angioedema (AE) were observed in African-American primary renal allograft recipients.
  • AE occurred upon initial exposure or re-initiation of SRL.
  • Patients were not on other medications known to cause AE.

Findings:

  • Sirolimus (SRL) was identified as the causative agent for angioedema (AE) in these cases.
  • Discontinuation of SRL led to complete resolution of AE.
  • AE did not recur after SRL withdrawal during follow-up.

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Implications:

  • Angioedema (AE) is a potential, previously unrecognized adverse event associated with Sirolimus (SRL) use.
  • Close monitoring for SRL-induced AE is warranted, especially in African-American transplant recipients.
  • This finding may influence clinical practice regarding SRL monitoring and patient selection.