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Related Experiment Videos

Recurrent status epilepticus in children.

S Shinnar1, J Maytal, L Krasnoff

  • 1Department of Neurology, Albert Einstein College of Medicine, Bronx, NY.

Annals of Neurology
|June 1, 1992
PubMed
Summary

Recurrent status epilepticus (SE) is a significant risk for children, particularly those with neurological abnormalities or remote symptomatic causes. Neurologically impaired children face a substantially higher risk of repeat SE episodes.

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Area of Science:

  • Pediatric Neurology
  • Epileptology
  • Clinical Pediatrics

Background:

  • Status epilepticus (SE) is a critical neurological emergency.
  • Limited data exists on the recurrence risk of SE in pediatric populations.
  • Understanding recurrence factors is vital for patient management and prognosis.

Purpose of the Study:

  • To prospectively evaluate the risk of recurrent status epilepticus in children after an initial episode.
  • To identify risk factors associated with SE recurrence in pediatric patients.
  • To analyze the causes and outcomes of recurrent SE in children.

Main Methods:

  • Prospective follow-up of 95 children experiencing their first episode of status epilepticus.
  • Classification of SE causes: idiopathic, febrile, acute symptomatic, remote symptomatic, and progressive neurological disorder.

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  • Mean follow-up duration of 29.0 months (range 4-60 months).

    • Main Results:

    • 17% of children experienced at least one recurrent episode of status epilepticus.
    • Recurrence risk varied significantly by etiology: 4% (idiopathic), 3% (febrile), 11% (acute symptomatic), 44% (remote symptomatic), and 67% (progressive neurological disorder).
    • Neurologically abnormal children had a significantly higher risk (88%) of recurrent SE compared to neurologically normal children (p < 0.001).

    Conclusions:

    • The risk of recurrent status epilepticus in children is influenced by the underlying cause, with remote symptomatic and progressive neurological disorders posing the highest risks.
    • Children with pre-existing neurological abnormalities are at a substantially increased risk for recurrent SE.
    • While SE recurrence can occur even with antiepileptic drug treatment, overall morbidity and mortality appear low.