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Related Experiment Videos

Copper deficiency myelopathy.

Neeraj Kumar1, Brian Crum, Ronald C Petersen

  • 1Department of Neurology, Mayo Clinic, Mayo Foundation, Rochester, Minn, USA. kumar.neeraj@mayo.edu

Archives of Neurology
|May 19, 2004
PubMed
Summary
This summary is machine-generated.

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Acquired copper deficiency can cause myelopathy, a spinal cord disorder, in humans. Measuring serum ceruloplasmin levels is crucial for diagnosing unexplained myelopathies.

Area of Science:

  • Neurology
  • Nutritional Neuroscience

Background:

  • Menkes disease, an inherited disorder, is a known cause of neurological issues due to copper deficiency.
  • Myelopathy from acquired copper deficiency is less recognized in humans, unlike in certain animal models.

Observation:

  • Three patients presented with progressive spastic-ataxic gait and proprioceptive deficits.
  • All observed patients exhibited significantly reduced serum ceruloplasmin and copper levels.

Findings:

  • Clinical and electrophysiological (somatosensory evoked potentials) studies confirmed posterior column dysfunction in all patients.
  • Spinal cord magnetic resonance imaging revealed posterior column signal changes in two of the three patients.

Implications:

Related Experiment Videos

  • Serum ceruloplasmin measurement should be considered in patients with unexplained myelopathies.
  • This highlights the importance of assessing copper status in neurological disorders.