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Arterio-embolic ischemic stroke in children with moyamoya disease

Peter Horn1, Eva Bueltmann, Christoph V Buch

  • 1Department of Neurosurgery, Universitätsklinikum Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany. peter.horn@nch.ma.uni-heidelberg.de

Child'S Nervous System : Chns : Official Journal of the International Society for Pediatric Neurosurgery
|May 19, 2004
PubMed

Insights

Moyamoya disease in children can cause severe stroke complications. Cerebral thromboembolism may play a significant role in stroke development and treatment strategies.

Area of Science:

  • Neurology
  • Pediatric Neurology
  • Cerebrovascular Diseases

Background:

  • Moyamoya disease is a rare steno-occlusive cerebrovascular disorder affecting children and adults.
  • In children, complications include developmental delay and intellectual disability from recurrent hemodynamic strokes.

Observation:

  • Two pediatric patients with Moyamoya disease experienced severe arterio-embolic ischemic events.
  • These patients had no underlying coagulopathy and were on antiplatelet therapy.

Findings:

  • Despite antiplatelet treatment, severe arterio-embolic ischemic complications occurred in pediatric Moyamoya disease.
  • Cerebral thromboembolism is a potential factor in the stroke pathophysiology for these patients.

Implications:

  • These findings suggest cerebral thromboembolism should be considered in the stroke pathophysiology of pediatric Moyamoya disease.
  • Understanding this impact may refine treatment approaches for children with Moyamoya disease.
Abstract

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