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The inflammatory response in mild and in severe psoriasis
P Rocha-Pereira1, A Santos-Silva, I Rebelo
1Departamento de Química da Universidade da Beira Interior, Rua Marquês d'Avila e Bolama, 6200 Covilhã, Portugal. petrorp@ciunix.ubi.pt
The British Journal of Dermatology
|May 20, 2004
Summary
Psoriasis involves neutrophil-driven inflammation and oxidative stress. Disease severity correlates with increased inflammation and an imbalance in neutrophil regulators, offering prognostic insights.
Area of Science:
- Dermatology
- Immunology
- Biochemistry
Background:
- Psoriasis is a chronic, relapsing inflammatory skin condition.
- Inflammation is a key protective response against pathogens and injury.
Purpose of the Study:
- Evaluate inflammatory response in mild and severe psoriasis.
- Assess endogenous systems that counteract inflammation.
- Identify prognostic markers for disease progression.
Main Methods:
- Compared 60 psoriasis patients (mild/severe) with 40 controls.
- Measured neutrophil activation markers (elastase, lactoferrin, lipid peroxidation).
- Assessed antioxidant/antiprotease systems (TAS, transferrin, ceruloplasmin, alpha(1)-antitrypsin, alpha(2)-macroglobulin) and inflammation markers (CRP, ESR, complement proteins).
Main Results:
- Psoriasis is characterized by neutrophil involvement, contributing to oxidative and proteolytic stress.
- Disease exacerbation is linked to heightened inflammation and a dysregulated balance between neutrophil products and inhibitors.
Conclusions:
- Proposed specific ratios (e.g., elastase/alpha(2)-macroglobulin) as prognostic indicators for psoriasis.
- Identified key inflammatory and oxidative stress markers with prognostic significance for disease worsening.