Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity
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Updated: Aug 24, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Timothy A Hill1, Luke R Odell, Annie Quan
1Advanced Synthetic Materials Group, Chemistry Building, School Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
Abstract:
We examined a number of ligands with the view of inhibiting the GTPase activity of dynamin. Dynamin contains a pleckstrin homology (PH) domain that interacts with lipids. We report a series of simple lipid-like molecules that display moderate inhibitory activity. Inhibitory activity is linked to chain length and quaternarization of the terminal amine. A change in the counterion, Cl versus Br or I, had little effect on potency. However, introduction of a hydrophobic collar proximal to the charged site was beneficial to dynamin GTPase inhibitory action. The most potent compound was myristoyl trimethyl ammonium bromide (MTMAB, IC(50) 3.15 microM).
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