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Preparation of alkylation agents for bulged DNA microenvironments
Farid S Fouad1, Zhen Xi, Irving H Goldberg
1Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA.
Abstract:
A designed molecule with capacity to alkylate DNA bulges has been prepared from readily available starting materials. The spirocyclic template utilized was designed on the basis of established architectures, and equipped with a mustard alkylating group. Preliminary studies confirm alkylation of specific bulged sequences, paving the way for second generation substrates with higher affinity.
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