Related Experiment Video
Updated: Aug 24, 2026
Software-Assisted Quantitative Measurement of Osteoarthritic Subchondral Bone Thickness
Published on: March 18, 2022
Computer-assisted quantitative analysis of bone marrow edema of the knee: initial experience with a new method
Marius E Mayerhoefer1, Martin Breitenseher, Siegfried Hofmann
1Department of Radiology, Surgical Radiology Section and Osteoradiology Section, University of Vienna, Waehringer Guertel 18-20, Vienna A-1090, Austria. marius_mayerhoefer@aon.at
Objective:
The purpose of this study was to describe a largely observer-independent computer-assisted method for accurate quantitative analysis of bone marrow edema.
Materials And Methods:
Ten patients with bone marrow edema of the knee were included in the study. Coronal STIR images of the affected knees were obtained using a 1.0-T MR scanner. Size and signal intensity of the bone marrow edema were assessed on the basis of gray-scale value analysis and calculation of a threshold value for differentiating normal and edematous bone marrow. All measurements were carried out three times for statistical analysis.
Results:
The intraobserver coefficient of variation was 0.89% for the volume and 0.94% for the signal intensity of the bone marrow edema, showing the small impact of manual interference on results produced with this method.
Conclusion:
A computer-assisted method for quantification of bone marrow edema has been described. Intraobserver variation was very low, indicating excellent reproducibility of results. Although the method is too time-consuming for clinical use, it is recommended for research purposes.
