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Whole-body 3D MR angiography of patients with peripheral arterial occlusive disease

Christoph U Herborn1, Mathias Goyen, Harald H Quick

  • 1Department of Diagnostic and Interventional Radiology, University Hospital Essen, Hufelandstrasse 55, Essen 45122, Germany. christoph.herborn@uni-essen.de

AJR. American Journal of Roentgenology
|May 20, 2004
PubMed

Insights

Whole-body 3D contrast-enhanced MR angiography accurately evaluates lower extremity arteries in peripheral arterial occlusive disease. This noninvasive imaging may reveal previously undetected vascular disease.

Area of Science:

  • Radiology
  • Cardiovascular Imaging
  • Vascular Disease Diagnostics

Background:

  • Peripheral arterial occlusive disease (PAOD) necessitates accurate lower extremity arterial assessment.
  • Digital subtraction angiography (DSA) is a standard but invasive diagnostic tool for PAOD.

Purpose of the Study:

  • To evaluate the diagnostic performance of whole-body 3D contrast-enhanced MR angiography (WB-MRA) compared to DSA for lower extremity arteries in PAOD patients.

Main Methods:

  • Fifty-one PAOD patients underwent WB-MRA on a 1.5-T scanner using gadobutrol contrast.
  • Lower extremity arterial imaging was performed using 3D T1-weighted gradient-echo sequences (72-second scan time).
  • DSA served as the reference standard; two radiologists performed blinded analyses.

Main Results:

  • WB-MRA was feasible and well-tolerated, demonstrating high sensitivity (92.3-93.1%) and specificity (87.6-89.2%) for high-grade stenoses.
  • Excellent interobserver agreement (kappa = 0.82) was observed.
  • Additional previously undetected vascular disease was identified in 23% of patients.

Conclusions:

  • WB-MRA provides a rapid, noninvasive, and accurate method for evaluating the lower peripheral arterial system in PAOD.
  • This technique has the potential to identify significant additional vascular disease not found by conventional methods.
Abstract

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