Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Optimization of a matrix tablet formulation using a mixture design.

P J Waaler1, C Graffner, B W Müller

  • 1Department of Pharmaceutics, Christian Albrechts University, Kiel, Germany.

Acta Pharmaceutica Nordica
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cortical thickness across the cingulate gyrus in schizophrenia and its association to illness duration and memory performance.

European archives of psychiatry and clinical neuroscience·2022
Same author

Investigation of decision-making under uncertainty in healthy subjects: a multi-centric fMRI study.

Behavioural brain research·2013
Same author

Attenuated prefrontal activation during decision-making under uncertainty in schizophrenia: a multi-center fMRI study.

Schizophrenia research·2013
Same author

Change of phase-solubility behavior by gamma-cyclodextrin derivatization.

Pharmaceutical research·2013
Same author

Release of gentamicin sulphate from biodegradable PLGA-implants produced by hot melt extrusion.

Die Pharmazie·2010
Same author

A new formulation concept for drugs with poor water solubility for parenteral application.

Die Pharmazie·2005
Same journal

Model systems in iontophoresis--transport efficacy.

Acta pharmaceutica Nordica·1992
Same journal

Role of temperature and moisture, on monomer content of freeze-dried human albumin.

Acta pharmaceutica Nordica·1992
Same journal

The alkaloids of the roots of Thalictrum flavum L.

Acta pharmaceutica Nordica·1992
Same journal

Effect of terminal heat sterilization on the stability of phospholipid-stabilized submicron emulsions.

Acta pharmaceutica Nordica·1992
Same journal

Effect of particle size on ocular permeability of prednisolone acetate in rabbits.

Acta pharmaceutica Nordica·1992
Same journal

Prodrugs of thiabendazole with increased water-solubility.

Acta pharmaceutica Nordica·1992
See all related articles

This study optimized modified release tablet formulations using simplex centroid design. Dicalcium phosphate and lactose content affected drug release and tablet properties, while microcrystalline cellulose showed opposite effects.

Area of Science:

  • Pharmaceutical Technology
  • Formulation Science

Background:

  • Modified release tablet formulations are crucial for sustained drug delivery.
  • Optimizing excipient ratios is key to achieving desired release profiles and mechanical properties.

Purpose of the Study:

  • To optimize a modified release tablet formulation containing naftidrofuryl.
  • To investigate the impact of microcrystalline cellulose, lactose, and dicalcium phosphate dihydrate on tablet characteristics.

Main Methods:

  • Simplex centroid design was employed for formulation optimization.
  • Mathematical models, including Scheffé's lattice method and multiple linear regression, were used for data analysis.
  • Response parameters included drug release rate, crushing strength, friability, and weight variation.

Related Experiment Videos

Main Results:

  • Regression analysis confirmed a good fit for the developed models.
  • Contour plots revealed that increased dicalcium phosphate lowered release rate and increased weight variation.
  • Higher lactose content reduced tablet strength and increased friability, while microcrystalline cellulose had opposing effects.

Conclusions:

  • The simplex centroid design effectively optimized the modified release tablet formulation.
  • Excipient composition significantly influences drug release kinetics and tablet physical properties.
  • Understanding these relationships allows for tailored tablet design to meet specific pharmaceutical requirements.