Related Experiment Video
Updated: Aug 24, 2026

Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
Published on: July 8, 2020
Secondary IgA nephropathy presenting as nephrotic syndrome with glomerular crescentic changes and acute renal failure
Naveen Singri1, Briana Gleason, Steve L Flamm
1Division of Nephrology and Hypertension, Feimberg School of Medicine, Northwestern University, Chicago 60611, USA.
Abstract:
Patients with end-stage liver disease are prone to hemodynamic and immunologic renal injury, the latter at times manifesting as glomerulonephritis. Elevated serum immunoglobulin A (IgA) levels and mesangial IgG-IgA deposits are common in these patients, but are often clinically silent. We report a patient with autoimmune hepatitis and secondary IgA nephropathy (IgAN) who presented with nephrotic syndrome, acute renal failure (ARF), with 30% of the renal glomeruli having undergone crescentic change, and with IgA2 deposits in the glomerular mesangium. This article discusses secondary IgAN pathogenesis and its therapeutic management.
More Related Videos
Related Concept Videos
Nephrotic Syndrome I : Introduction
Acute Kidney Injury III: Clinical Manifestations
Nephrotic Syndrome II : Assessment and Medical Management
Acute Kidney Injury I: Introduction
Acute Kidney Injury II: Pathophysiology
Diabetic Nephropathy

