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What are the limits to the size of effective dynamic combinatorial libraries?
Peter T Corbett1, Sijbren Otto, Jeremy K M Sanders
1Cambridge University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW, U.K.
Organic Letters
|May 21, 2004
Abstract:
Using simple computer simulations of model dynamic combinatorial libraries, we show that the best binders can be amplified to useful concentrations in libraries containing 10-10(6) compounds. [structure: see text]