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Updated: Aug 24, 2026
Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
Published on: November 24, 2017
[Study of NMDAR expression in hippocampal CA(1) region in neonatal rats with hypoxic-ischemia]
Yan-Hua Cao1, Ling Wang, Yu-Hong Cao
1Department of Pediatrics, Tangdu Hospital,Fourth Military Medical University, Xi'an 710038,China.
Aim:
To study the expressions of NMDAR in hippocampal CA(1) region after hypoxic-ischemic brain damage(HIBD) in neonatal rats.
Methods:
An neonatal rat model with hypoxic-ischemic brain damage was set up. The expression of NMDAR was detected in normal control and hypoxic-ischemic (HI) brain damage group by immunohistochemical staining and in situs hybridization.
Results:
The number of NR1(+) and NR1 mRNA(+) cells decreased slightly in hippocampal CA(1) region at 2 h after HI. The numbers increased from 24 h to 48 h after HI, and reached maximum at 72 h after HI.
Conclusion:
NR1 expressed in hippocampal CA(1) region of normal neonatal rats, and the expression is up-regulated after HI brain injury.