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Updated: Aug 19, 2026

In Vitro and In Vivo Approaches to Determine Intestinal Epithelial Cell Permeability
Published on: October 19, 2018
[Intestinal permeability of patients with advanced digestive tract malignant tumors]
Yu-chuan Yao1, Cun-long Chen, Ji-de Wang
1Institute for Digestive Diseases of PLA, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China. yaoge1972@163.com
Objective:
To assess the intestinal barrier function of patients with advanced digestive tract malignant tumors by measuring the changes in intestinal permeability.
Methods:
Sixteen patients with digestive tract tumors and 16 healthy volunteers were enrolled. After oral administration of mannitol and lactulose in deionized water, the 6-hour urine samples were collected for analyzing mannitol and lactulose concentrations using gas-liquid chromatography.
Results:
Urine lactulose concentration and lactulose/mannitol (L/M) ratio of the tumor patients were increased in comparison with those of the healthy subjects (P<0.05).
Conclusion:
he intestinal permeability increased in these tumor patients, indicating intestinal barrier dysfunction.
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