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Updated: Aug 10, 2026
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Published on: October 27, 2014
A phase II study of carboplatin and paclitaxel in esophageal cancer
B F El-Rayes1, A Shields, M Zalupski
1Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
Background:
This study was conducted to evaluate the efficacy and toxicity of combination carboplatin and paclitaxel in patients with esophageal cancer.
Materials And Methods:
Thirty-five patients were enrolled. Patients were treated with paclitaxel 200 mg/m(2) intravenously (i.v.) over 3 h and carboplatin i.v. at an AUC of 5 mg/h/ml. Thirty-three patients were assessable for toxicity and objective response.
Results:
A total of 166 treatment courses were administered with a median of five courses per patient. The objective response rate was 43% [90% confidence interval (CI) 0.3-0.58] by the intention-to-treat analysis. The median response duration was 2.8 months (90% CI 2.1-5.4). The median survival time was 9 months (90% CI 7-13.8) and the 1-year survival rate was 43% (90% CI 0.29-0.57). The major grade 3-4 toxicity observed was neutropenia, occurring in 17 patients (52%). There were no treatment-related deaths.
Conclusions:
The combination of carboplatin and paclitaxel is an moderately active and tolerable regimen in advanced esophageal cancer.
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