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[Neonatal seizures, our experience].

E Alcover-Bloch1, J Campistol, M Iriondo-Sanz

  • 1Servicio de Neurología, Unidad Integrada, Hospital Sant Joan de Déu, Esplugues de Ll., Barcelona, Spain.

Revista De Neurologia
|May 21, 2004
PubMed
Summary

Neonatal seizures in newborns can lead to poor outcomes, particularly those caused by malformations or hypoxic ischemic encephalopathy. Early diagnosis and treatment are crucial for improving seizure management and long-term prognosis.

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Area of Science:

  • Neonatal Neurology
  • Pediatric Epilepsy
  • Clinical Pediatrics

Context:

  • Neonatal seizures represent a significant clinical challenge.
  • Understanding the etiology and outcomes of neonatal seizures is critical for effective management.
  • This study retrospectively analyzes newborns with seizures within the first month of life.

Purpose:

  • To investigate the characteristics, etiologies, treatments, and outcomes of neonatal convulsions.
  • To identify risk factors associated with adverse neurological outcomes in neonates with seizures.
  • To compare the outcomes based on different etiological categories.

Summary:

  • The study included 77 newborns with seizures, with hypoxic ischemic encephalopathy being the most common etiology (39%).
  • Abnormal findings were frequent on neuroimaging (ultrasound, CT/MRI) and EEG.
  • Phenobarbital was the primary treatment, but many required changes, and over half were still on medication at discharge. A significant proportion (45.4%) had abnormal outcomes, including cognitive delay and epilepsy.
  • Outcomes varied by etiology, with malformations, meningitis, intracranial hemorrhages, metabolic diseases, and hypoxic ischemic encephalopathy associated with worse prognoses, while hypoglycemia and benign idiopathic neonatal seizures had better outcomes.

Impact:

  • Provides insights into the current landscape of neonatal seizures, highlighting the persistent challenges in diagnosis and treatment.
  • Informs clinical practice regarding the long-term prognosis associated with specific etiologies of neonatal seizures.
  • Contributes to the understanding of neonatal neurological disorders and guides future research directions.

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