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Isolation and Expansion of Human Glioblastoma Multiforme Tumor Cells Using the Neurosphere Assay
Published on: October 30, 2011
[Cerebellar glioblastoma multiforme: a case report]
A Pato-Pato1, I Cimas-Hernando, J R Lorenzo-González
1Sección de Neurología, Hospital Povisa, Vigo, Pontevedra. patopatonrl@mixmail.com
Revista De Neurologia
|May 21, 2004
Summary
Cerebellar glioblastoma multiforme (CGM) is a rare brain tumor with a poor prognosis. Early diagnosis via MRI and surgical resection followed by radiotherapy are crucial for management.
Area of Science:
- Neuro-oncology
- Neurosurgery
- Radiology
Background:
- Cerebellar glioblastoma multiforme (CGM) is a rare variant, comprising less than 1% of all glioblastomas.
- CGM typically presents with rapid local spread and a poor prognosis.
Observation:
- A 55-year-old patient presented with dizziness, instability, vomiting, and double vision.
- Neurological examination revealed facial hypesthesia, contralateral sensory deficits, and nystagmus.
- MRI identified a 3 cm lesion in the cerebellum with characteristic enhancement and edema.
Findings:
- Pathological analysis confirmed glioblastoma multiforme.
- Subtotal tumor excision was performed, followed by radiotherapy and chemotherapy.
Implications:
- CGM diagnosis requires a differential including metastasis, infarction, and abscesses, aided by MRI.
- Optimal treatment involves surgical debulking, radiotherapy, and potentially chemotherapy, though its role remains under investigation.
