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[Antidepressants in migraine prophylaxis: an approximation].

A Campo-Arias1

  • 1Grupo de Neuropsiquiatría UNAB, Facultad de Medicina, Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia. acampoar@unab.edu.co

Revista De Neurologia
|May 21, 2004
PubMed
Summary

Antidepressants are effective for preventing migraines, especially in patients with co-occurring major depressive disorder (MDD). Amitriptyline and fluoxetine show efficacy in managing migraine prophylaxis with a favorable safety profile.

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Area of Science:

  • Neurology
  • Psychiatry
  • Pharmacology

Context:

  • Migraine is a common neurological disorder.
  • Major Depressive Disorder (MDD) is a prevalent mental health condition.
  • High comorbidity exists between migraine and MDD, suggesting complex interactions.

Purpose:

  • To evaluate the efficacy of antidepressants in migraine prophylaxis.
  • To explore the role of antidepressants in managing comorbid migraine and MDD.

Summary:

  • Antidepressants, particularly those acting on 5-HT2 receptors, are beneficial for migraine prevention.
  • Specific antidepressants like amitriptyline and fluoxetine have demonstrated effectiveness in clinical trials.
  • These drugs offer a low toxicity profile with minimal serious side effects, making them a safe option.

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Impact:

  • Antidepressants represent a primary prophylactic treatment for migraine, especially when associated with MDD.
  • Provides evidence-based recommendations for antidepressant use in migraine management.
  • Highlights the therapeutic potential of antidepressants in a complex comorbidity.