Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Vancomycin resistant enterococci in the Netherlands].

H L Leavis1, R J Willems, E M Mascini

  • 1Universitair Medisch Centrum Utrecht, afd. Acute Interne Geneeskunde/Eijkman-Winkler Instituut, Postbus 85.500, 3508 GA Utrecht.

Nederlands Tijdschrift Voor Geneeskunde
|May 22, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prolonged Disease Course of COVID-19 in a Patient with CTLA-4 Haploinsufficiency.

Case reports in immunology·2023
Same author

Case series of three adult patients with exceptional clinical presentations of haemophagocytic lymphohistiocytosis.

The Netherlands journal of medicine·2020
Same author

A dominant activating RAC2 variant associated with immunodeficiency and pulmonary disease.

Clinical immunology (Orlando, Fla.)·2019
Same author

Friend or foe: how intestinal microbiome contribute to health and disease states.

The Netherlands journal of medicine·2019
Same author

Monitoring of tobramycin serum concentrations in selected critically ill patients receiving selective decontamination of the digestive tract: a retrospective evaluation.

European journal of clinical pharmacology·2019
Same author

Management of community-acquired pneumonia in adults: 2016 guideline update from the Dutch Working Party on Antibiotic Policy (SWAB) and Dutch Association of Chest Physicians (NVALT).

The Netherlands journal of medicine·2018
Same journal

[Insulin intoxications caused by falsified semaglutide].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Professional skepticism in medical research].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[Improving mobility in painful osteoarthritis].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The effectiveness and costs of the Back At work After Surgery (BAAS) work-integrated care pathway on return to work for patients receiving knee arthroplasty].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[The rise of genetic therapies: urgent moral and societal questions].

Nederlands tijdschrift voor geneeskunde·2026
Same journal

[A man with a wound on his elbow].

Nederlands tijdschrift voor geneeskunde·2026
See all related articles

Vancomycin-resistant enterococci (VRE) infections are a growing concern, especially in hospitals. Effective infection control measures, implemented in the Netherlands since 2000, successfully managed VRE outbreaks and continue to be recommended.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Context:

  • Enterococci, particularly Enterococcus faecalis and Enterococcus faecium, are opportunistic pathogens causing infections mainly in immunocompromised individuals.
  • Intrinsic antibiotic resistance in enterococci complicates treatment, with vancomycin historically serving as a last-resort antibiotic.
  • The emergence and spread of vancomycin-resistant enterococci (VRE) pose a significant global health threat, particularly in hospital settings.

Purpose:

  • To review the emergence and management of vancomycin-resistant enterococci (VRE) outbreaks in Dutch hospitals.
  • To highlight the characteristics of a specific 'hospital strain' of E. faecium associated with outbreaks.
  • To emphasize the importance of infection control measures in preventing VRE transmission and the potential for gene transfer to other resistant bacteria.

Related Experiment Videos

Summary:

  • Plasmid-mediated vancomycin resistance in enterococci, first identified in the 1980s, has led to a dramatic increase in VRE infections, especially in the US.
  • A specific subpopulation of E. faecium, characterized by a virulence gene (esp) and amoxicillin resistance, has been implicated in hospital outbreaks worldwide.
  • Infection control measures implemented in Dutch hospitals in 2000 successfully controlled three VRE outbreaks, with no further outbreaks reported since.

Impact:

  • The successful management of VRE outbreaks in the Netherlands underscores the efficacy of targeted infection control strategies.
  • Understanding the characteristics of virulent VRE strains is crucial for developing effective prevention and treatment protocols.
  • The demonstrated transfer of vancomycin resistance from VRE to MRSA highlights the urgent need for continued surveillance and control of both VRE and MRSA in healthcare settings.