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Oral ketamine premedication can prevent emergence agitation in children after desflurane anaesthesia

Alper Kararmaz1, Sedat Kaya, Selim Turhanoglu

  • 1Department of Anaesthesiology, Dicle University Hospital, Diyarbakir, Turkey. akararmaz@ixir.com

Paediatric Anaesthesia
|May 22, 2004
PubMed

Insights

Oral ketamine premedication significantly reduced emergence agitation in children undergoing adenotonsillectomy. This intervention did not delay patient recovery, offering a promising strategy for improving pediatric anesthesia outcomes.

Area of Science:

  • Anesthesiology
  • Pediatric Surgery

Background:

  • Emergence agitation is a common complication following pediatric anesthesia.
  • Identifying effective interventions to mitigate this issue is crucial for patient well-being.

Purpose of the Study:

  • To investigate the efficacy of oral ketamine premedication in reducing the incidence of emergence agitation in children.
  • To assess the impact of oral ketamine on emergence and recovery times.

Main Methods:

  • A randomized controlled trial involving 80 children undergoing adenotonsillectomy.
  • Children received either oral ketamine (6 mg/kg) or sour cherry juice 30 minutes before anesthesia induction.
  • Postoperative behavior was assessed using a 5-point agitation scale.

Main Results:

  • The incidence of emergence agitation was significantly lower in the ketamine group (18%) compared to the control group (56%).
  • Time to eye opening was significantly longer in the ketamine group, but overall emergence and recovery times were not significantly delayed.

Conclusions:

  • Oral ketamine premedication is effective in reducing post-anesthesia emergence agitation in children.
  • Ketamine administration did not lead to significant delays in recovery, suggesting a favorable safety profile for this indication.
Abstract

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