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Related Experiment Videos

Lichen planus and Hepatitis C: a case-control study.

S Zahra Ghodsi1, Maryam Daneshpazhooh, Mohammad Shahi

  • 1Department of Dermatology, Tehran University of Medical Sciences Razi Hospital, Vahdat Islami Square, 11996 Tehran, Iran. zghodsi@ut.ac.ir

BMC Dermatology
|May 22, 2004
PubMed
Summary
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Hepatitis C (HCV) infection is significantly more common in Iranian patients with lichen planus than in blood donors. This suggests a potential role for HCV in causing lichen planus in this population.

Area of Science:

  • Hepatology
  • Dermatology
  • Epidemiology

Background:

  • Lichen planus (LP) is associated with hepatitis C virus (HCV) infection.
  • Geographical variations exist in HCV prevalence among LP patients.
  • This study investigated HCV frequency in Iranian LP patients.

Purpose of the Study:

  • To determine the prevalence of hepatitis C virus (HCV) infection in Iranian patients diagnosed with lichen planus (LP).
  • To assess the association between HCV infection and LP in a specific Iranian population.
  • To evaluate the utility of liver function tests in screening for HCV in LP patients.

Main Methods:

  • 146 lichen planus (LP) cases (1997-1998) were clinically and histologically diagnosed.
  • Patients were screened for anti-HCV antibodies using third-generation ELISA.

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  • Blood donor screening data served as the control group.

    • Main Results:

    • Anti-HCV antibodies were detected in 4.8% of LP patients, significantly higher than controls (p < 0.001).
    • A strong association (Odds Ratio 50.37) was found between erosive LP and HCV infection.
    • Liver function tests did not differ significantly between HCV-infected and non-infected LP patients.

    Conclusions:

    • Hepatitis C virus (HCV) likely plays an etiological role in lichen planus (LP) among Iranian patients.
    • Liver function tests are not reliable for screening HCV infection in LP patients.
    • Further research may elucidate the specific mechanisms linking HCV and LP.