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Related Experiment Videos

Tutorial section: domains and motifs - proteins in bite-sized chunks.

Lisa Mullan1

  • 1MRC Rosalind Franklin Centre for Genomics Research (formerly HGMP-RC), Genome Campus, Hinxton, Cambridge CB10 1SB, UK. lmullan@hrfcgr.mrc.ac.uk

Briefings in Bioinformatics
|May 22, 2004
PubMed
Summary

Predicting protein structure from amino acid sequences remains a major challenge in bioinformatics. Despite decades of research, a reliable method for protein folding prediction is still elusive for scientists.

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Briefings in bioinformatics·2004

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Structural Biology

Background:

  • The prediction of protein tertiary structure and chemical functionality from amino acid sequences is a fundamental goal in bioinformatics.
  • Despite significant research efforts over two decades, a reliable protein structure modeling method has not yet been established.

Purpose of the Study:

  • To highlight the ongoing challenges in predicting protein tertiary structure.
  • To emphasize the significance of the protein folding problem in scientific research.

Main Methods:

  • Review of existing bioinformatics and computational biology approaches.
  • Analysis of the limitations in current protein structure prediction techniques.

Main Results:

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  • The protein folding problem continues to be a significant hurdle.
  • A reliable method for predicting protein tertiary structure from amino acid sequence is still lacking.

Conclusions:

  • The ultimate goal of predicting protein structure and function from sequence remains unmet.
  • Further research and development of novel modeling methods are crucial for advancing bioinformatics and structural biology.