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Changes in blood viscosity with mucopolysaccharide polysulfate
Masahito Hitosugi1, Kazunobu Omura, Masahito Kido
1Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan. hitosugi@dokkyomed.ac.jp
Journal of Pharmacological Sciences
|May 22, 2004
Summary
Mucopolysaccharide polysulfate (MPS) effectively reduces blood clotting factors and viscosity in a dose-dependent manner, similar to heparin. Topical application may improve local blood flow.
Area of Science:
- Biochemistry
- Hematology
- Pharmacology
Background:
- Blood viscosity and coagulation are critical factors in circulatory health.
- Mucopolysaccharide polysulfate (MPS) is a substance with potential anticoagulant properties.
- Understanding MPS's effects on coagulation and viscosity is essential for therapeutic applications.
Purpose of the Study:
- To investigate the dose-dependent effects of MPS on human blood coagulation.
- To assess the impact of MPS on whole-blood viscosity.
- To compare MPS's efficacy with heparin sodium.
Main Methods:
- Human blood samples were treated with varying concentrations of MPS (0.01% and 0.1%).
- Coagulation variables, including fibrin monomer and thrombin-antithrombin III complex, were measured.
- Whole-blood viscosity was determined using an oscillation viscometer.
- Comparisons were made with heparin sodium (2.0 IU/ml).
Main Results:
- MPS significantly reduced fibrin monomer and thrombin-antithrombin III complex levels at both tested concentrations.
- The anticoagulant effect of MPS was comparable to that of heparin sodium.
- MPS demonstrated a dose-dependent decrease in whole-blood viscosity.
- Higher concentrations of MPS led to greater reductions in viscosity.
Conclusions:
- Mucopolysaccharide polysulfate exhibits significant dose-dependent anticoagulant and viscosity-reducing effects in human blood.
- MPS shows comparable efficacy to heparin sodium in inhibiting key coagulation markers.
- Percutaneous application of MPS, potentially via creams or gels, may offer a viable strategy for reducing local whole-blood viscosity and improving venous blood flow.