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Changes in blood viscosity with mucopolysaccharide polysulfate

Masahito Hitosugi1, Kazunobu Omura, Masahito Kido

  • 1Department of Legal Medicine, Dokkyo University School of Medicine, Tochigi, Japan. hitosugi@dokkyomed.ac.jp

Journal of Pharmacological Sciences
|May 22, 2004
PubMed

Insights

Mucopolysaccharide polysulfate (MPS) effectively reduces blood clotting factors and viscosity in a dose-dependent manner, similar to heparin. Topical application may improve local blood flow.

Area of Science:

  • Biochemistry
  • Hematology
  • Pharmacology

Background:

  • Blood viscosity and coagulation are critical factors in circulatory health.
  • Mucopolysaccharide polysulfate (MPS) is a substance with potential anticoagulant properties.
  • Understanding MPS's effects on coagulation and viscosity is essential for therapeutic applications.

Purpose of the Study:

  • To investigate the dose-dependent effects of MPS on human blood coagulation.
  • To assess the impact of MPS on whole-blood viscosity.
  • To compare MPS's efficacy with heparin sodium.

Main Methods:

  • Human blood samples were treated with varying concentrations of MPS (0.01% and 0.1%).
  • Coagulation variables, including fibrin monomer and thrombin-antithrombin III complex, were measured.
  • Whole-blood viscosity was determined using an oscillation viscometer.
  • Comparisons were made with heparin sodium (2.0 IU/ml).

Main Results:

  • MPS significantly reduced fibrin monomer and thrombin-antithrombin III complex levels at both tested concentrations.
  • The anticoagulant effect of MPS was comparable to that of heparin sodium.
  • MPS demonstrated a dose-dependent decrease in whole-blood viscosity.
  • Higher concentrations of MPS led to greater reductions in viscosity.

Conclusions:

  • Mucopolysaccharide polysulfate exhibits significant dose-dependent anticoagulant and viscosity-reducing effects in human blood.
  • MPS shows comparable efficacy to heparin sodium in inhibiting key coagulation markers.
  • Percutaneous application of MPS, potentially via creams or gels, may offer a viable strategy for reducing local whole-blood viscosity and improving venous blood flow.

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