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Updated: Aug 24, 2026
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Published on: February 12, 2017
Docetaxel and carboplatin as first-line therapy in advanced non-small cell lung carcinoma: a phase II study
Mohammad Jahanzeb1, Greg Sarna, Robert Hirsch
1University of Tennessee Cancer Institute, 1331 Union Avenue-Suite 800, Memphis, TN 38104, USA. mjahanze@utmem.edu
Background:
Taxanes have been widely used against advanced non-small cell lung cancer (NSCLC), alone and in combination with platinum agents. In order to develop a tolerable palliative regimen, we combined carboplatin with low dose docetaxel.
Patients And Methods:
Chemotherapy-naive patients, with Stage IIIB or IV NSCLC and an ECOG performance status < or = 2, were enrolled. Treatment consisted of docetaxel 60 mg/m2 and carboplatin AUC 6 every 21 days. Therapy continued for 1 year or 6 months beyond best response, whichever was greater.
Results:
Twenty-five patients were enrolled. Most patients (80%) had Stage IV disease. The partial response rate was 16%. Response duration ranged from 6 to 115 weeks. Median survival was 55 weeks. Toxicity was generally limited to grade 3 or 4 neutropenia. There was 1 septic death.
Conclusion:
Survival compared favorably to other similar trials employing higher doses of docetaxel. Additionally, a hematologic toxicity advantage was seen compared to regimens containing higher doses of docetaxel.
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