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Related Experiment Videos

The amygdala and persistent pain.

Volker Neugebauer1, Weidong Li, Gary C Bird

  • 1Department of Anatomy & Neurosciences, University of Texas Medical Branch, Galveston, 77555-1069, USA. voneugeb@utmb.edu

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
|May 25, 2004
PubMed
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The amygdala, particularly the "nociceptive amygdala," plays a dual role in pain processing and emotional responses. Neuroplastic changes in the amygdala may underlie persistent pain and its affective modulation.

Area of Science:

  • Neuroscience
  • Pain Research
  • Affective Science

Background:

  • A bidirectional link exists between chronic pain and negative emotions like anxiety and depression.
  • The amygdala is increasingly recognized for its role in emotional processing and affective disorders.
  • Its contribution to pain perception and emotional components of pain is an emerging area of research.

Purpose of the Study:

  • To review and discuss evidence implicating the amygdala in pain modulation and emotional responses to pain.
  • To highlight the emerging role of the amygdala in the interplay between pain and affective states.

Main Methods:

  • Review of anatomical, neuroimaging, behavioral, electrophysiological, pharmacological, and biochemical data.
  • Definition and discussion of the "nociceptive amygdala" (latero-capsular division of the central nucleus).

Related Experiment Videos

  • Examination of evidence for neuroplastic changes in the nociceptive amygdala.

    • Main Results:

    • The amygdala integrates nociceptive information with bodily environmental data.
    • The amygdala exhibits a dual (facilitatory and inhibitory) role in pain modulation.
    • Recent findings show neuroplastic changes in the nociceptive amygdala associated with persistent pain.

    Conclusions:

    • The amygdala is a key site for the interaction between persistent pain and negative affective states.
    • The "nociceptive amygdala" plays a critical role in processing pain and its emotional aspects.
    • Amygdala plasticity is likely involved in emotional pain behaviors and their modulation by affective states.