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Related Experiment Video

Updated: Jan 8, 2026

Automated Preparation of [68Ga]Ga-3BP-3940 on a Synthesis Module for PET Imaging of the Tumor Microenvironment
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Efaproxiral: a novel radiation sensitiser.

John H Suh1

  • 1Brain Tumour Institute, Department of Radiation Oncology, T28 Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA. suh@radonc.ccf.org

Expert Opinion on Investigational Drugs
|May 25, 2004
PubMed
Summary

Efaproxiral (RSR13) enhances tumor oxygenation by reducing hemoglobin

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Area of Science:

  • Pharmacology
  • Oncology
  • Radiation Biology

Background:

  • Hypoxia in tumors reduces radiation therapy effectiveness.
  • Efaproxiral (RSR13) is a synthetic allosteric modifier of hemoglobin.
  • It decreases oxygen binding affinity, increasing tissue oxygen partial pressure (PO2).

Purpose of the Study:

  • To evaluate efaproxiral as a radiation sensitizer.
  • To enhance tumor oxygenation and overcome hypoxia-induced radioresistance.

Main Methods:

  • Administration of efaproxiral to increase whole blood P50.
  • Facilitation of oxygen release from hemoglobin to tissues.
  • Clinical trials (Phase I-III) to assess safety and efficacy.

Main Results:

  • Efaproxiral increases tissue PO2, potentially improving tumor oxygenation.
  • It acts as a radiation sensitizer without needing to enter cancer cells.
  • Phase I-III trials established its safety profile and dosing.

Conclusions:

  • Efaproxiral shows potential as a radiation sensitizer by improving tumor oxygenation.
  • Its mechanism of action differs from traditional radiation sensitizers.
  • Clinical data suggest potential for extended survival.

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