Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vaccination with T cell-defined antigens.

Monica C Panelli1, Ena Wang, Vladia Monsurrò

  • 1Immunogenetics Section, Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892, USA. FMarincola@cc.nih.gov

Expert Opinion on Biological Therapy
|May 25, 2004
PubMed
Summary

T cells are highly specific anticancer agents due to their ability to recognize tumor cells. While T cell therapy shows promise, other immune components are crucial for complete cancer rejection.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Topical TLR7 agonist and radiotherapy in patients with metastatic breast cancer.

Journal for immunotherapy of cancer·2025
Same author

An integrated tumor, immune and microbiome atlas of colon cancer.

Nature medicine·2023
Same author

Flt3 ligand augments immune responses to anti-DEC-205-NY-ESO-1 vaccine through expansion of dendritic cell subsets.

Nature cancer·2022
Same author

MicroRNA Expression Profile Distinguishes Glioblastoma Stem Cells from Differentiated Tumor Cells.

Journal of personalized medicine·2021
Same author

Multiply restimulated human thymic regulatory T cells express distinct signature regulatory T-cell transcription factors without evidence of exhaustion.

Cytotherapy·2021
Same author

The MAPK hypothesis: immune-regulatory effects of MAPK-pathway genetic dysregulations and implications for breast cancer immunotherapy.

Emerging topics in life sciences·2021

Area of Science:

  • Tumor immunology
  • Cancer immunotherapy
  • Cellular immunology

Background:

  • Tumor immunology involves complex interactions between cancer cells and the immune system.
  • T cells are key players in adaptive immunity, capable of specific tumor cell recognition.
  • Intracellular tumor antigens favor T cell-mediated cancer attack over antibodies or innate immunity.

Purpose of the Study:

  • To highlight T cells as a unique anticancer agent with absolute specificity.
  • To emphasize the role of T cells in tumor immunology and cancer therapy.
  • To acknowledge the limitations of T cells and the necessity of other immune components.

Main Methods:

  • This is a review article, not an experimental study.
  • The review focuses on the immunological rationale for T cell-based cancer therapy.

Related Experiment Videos

  • Discussion of comparative efficacy with other modalities is excluded.

    • Main Results:

    • T cells offer absolute specificity in targeting cancer cells.
    • T cells can be educated via antigen-specific immunization for cancer recognition.
    • The review argues for the unique potential of T cells in cancer treatment.

    Conclusions:

    • T cells are a distinct and highly specific anticancer therapeutic agent.
    • Complete cancer rejection likely requires a multifaceted approach involving T cells and other immune factors.
    • Tumor heterogeneity and host genetics also play significant roles in cancer immunology.