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Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs
Published on: December 9, 2010
Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human
Gary D Ewart1, Najla Nasr, Hassan Naif
1Biotron Limited, LPO Box A315, Eggleston Rd., Australian National University, Canberra, ACT 2601, Australia. gewart@biotron.com.au
Abstract:
We report that the amiloride analogues 5-(N,N-hexamethylene)amiloride and 5-(N,N-dimethyl)amiloride inhibit, at micromolar concentrations, the replication of human immunodeficiency virus type 1 (HIV-1) in cultured human blood monocyte-derived macrophages. These compounds also inhibit the in vitro activities of the HIV-1 Vpu protein and might represent lead compounds for a new class of anti-HIV-1 drugs.
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