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Updated: Aug 24, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
Change in bispectral index during epileptiform electrical activity under sevoflurane anesthesia in a patient with
Mieko Chinzei1, Shigehito Sawamura, Masakazu Hayashida
1*Surgical Centre, Graduate School of Medicine, and †Department of Anesthesiology and Pain Relief Center, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
Unlabelled:
We observed abnormal fluctuation in Bispectral Index (BIS) caused by repeated alternations between two electroencephalographic (EEG) waveform patterns in a patient with a recent history of epileptic seizure under sevoflurane anesthesia. The repetitive development of the abnormal EEG changes (slow delta with or without spike) and the fluctuation in BIS disappeared almost immediately after administration of anticonvulsants. BIS may give useful information not only on the sedative-hypnotic state, but also on the development of and recovery from abnormal epileptiform EEG activity.
Implications:
During epileptiform electroencephalographic activity (EEG), the Bispectral Index shows an abnormal fluctuation caused by repeated abrupt alterations between normal EEG and abnormal epileptiform EEG patterns.
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