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Bacteraemia due to Staphylococcus aureus.

S Ladhani1, O S Konana, S Mwarumba

  • 1Centre for Geographic Medicine Research, Coast, KEMRI, Kenya. drshamez@aol.com

Archives of Disease in Childhood
|May 25, 2004
PubMed
Summary
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Staphylococcus aureus bloodstream infections in Kenyan children often lack typical signs, especially in neonates. Early antibiotics are crucial, as mortality is significantly higher in children without a clear infection focus.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Microbiology

Background:

  • Staphylococcus aureus bloodstream infections (bacteraemia) pose a significant threat to children.
  • Understanding clinical features and outcomes is vital for effective management, particularly in resource-limited settings.

Purpose of the Study:

  • To describe the clinical characteristics and outcomes of Staphylococcus aureus bacteraemia in children admitted to a rural Kenyan hospital.
  • To identify risk factors associated with mortality.

Main Methods:

  • Retrospective case review of pediatric patients with S. aureus bacteraemia.
  • Data collected from Kilifi District Hospital, Kenya (1996-2001).
  • Analysis of clinical features, treatment, and outcomes, including mortality.

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Main Results:

  • 97 children had S. aureus bacteraemia (5% of positive blood cultures); 10 were nosocomial.
  • 52 cases had a clinical staphylococcal infection focus, often multifocal.
  • Mortality was 6% with a focus vs. 47% without; 10/13 neonates without a focus died.

Conclusions:

  • Children at highest risk of death from S. aureus bacteraemia often lack typical clinical features.
  • Prompt and appropriate antibiotic therapy, especially in neonates, is critical for improving outcomes.