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The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans
Christina M Hull1, Gary M Cox, Joseph Heitman
1Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Abstract:
Cryptococcus neoformans is a human fungal pathogen that has two mating types (a and alpha). Experiments have shown that in some backgrounds alpha strains are more virulent than a strains. Our studies reveal that the only known alpha-specific factor, SXI1alpha, is not necessary for virulence.
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