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Updated: Aug 24, 2026

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Published on: March 20, 2014
Hyperexcitability-associated rapid plasticity after a focal cerebral ischemia
Hiroshi Fujioka1, Hidekazu Kaneko, Shinya S Suzuki
1Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan. e909eb@yamaguchi-u.ac.jp
Background And Purpose:
This article addresses how neuroplastic changes are initiated after an ischemic stroke.
Methods:
A focal cerebral ischemia was photochemically induced on the primary somatosensory cortex of rats, and in vivo electrophysiological recordings were performed on the peri-infarct cortex before and from 1 to 6 hours after the infarction.
Results:
Paired-pulse analysis of evoked field potentials to peripheral electrical stimuli showed statistically significant neuronal hyperexcitability that was associated with rapid expansion of receptive fields (146.1% at 1 hour and 553.6% at 6 hours) as early as 1 hour after the infarction (P<0.05). Current source density analysis revealed increased current sinks in cortical layer II/III.
Conclusions:
Our electrophysiological results showed, for the first time to our knowledge, rapid plastic changes in the peri-infarct cortex during the hyperacute stage of an ischemic stroke. Manipulation of this rapid plasticity may affect subsequent plastic changes.
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