Related Experiment Video
Updated: Aug 24, 2026

A High-throughput Compatible Assay to Evaluate Drug Efficacy against Macrophage Passaged Mycobacterium tuberculosis
Published on: March 24, 2017
Comparison of the effectiveness of five different antibiotic regimens on infection with Rickettsia typhi: therapeutic
Achilleas Gikas1, Stephanos Doukakis, John Pediaditis
1Clinical Bacteriology, Parasitology Zoonoses, and Geographic Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece. gikas@med.uoc.gr
Abstract:
This study estimated the clinical effectiveness of five different antibiotic regimens (doxycycline, chloramphenicol, ciprofloxacin, doxycycline plus chloramphenicol, and doxycycline plus ciprofloxacin) administered for infection with Rickettsia typhi in terms of the duration of the fever. Eighty-seven patients with endemic typhus were hospitalized between 1993 and 1998 at the General Hospital of Chania in Chania, Crete, Greece. The mean time to defervescence was 2.9 days for doxycycline, 4.0 days for chloramphenicol, and 4.2 days for ciprofloxacin. In patients receiving combinations of doxycycline plus chloramphenicol and doxycycline plus ciprofloxacin, fever subsided in 3.4 and 4.0 days, respectively. The outcome was favorable in all patients, and no deaths or relapses were observed within two months.
Related Concept Videos
Rocky Mountain Spotted Fever
Pulmonary Tuberculosis V
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Antimicrobial Effectiveness
